Principal Computational Methodologist

Salary: £70,000 - 110,000 per year

Requirements:

• We are looking for a PhD in Statistics, Computer Science, Engineering, Computational Biology, Statistical Genetics, Mathematics, or a related scientific field.
• We are looking for experience in industry, ideally within pharma, clinical development, life sciences, or another regulated data-focused environment.
• We are looking for confident programming ability in Python, R, or similar languages, with the ability to support others with practical coding guidance.
• We are looking for understanding of supervised, unsupervised, Bayesian, and deep learning methods, with the ability to apply them to real-world scientific questions.
• We are looking for experience with ML infrastructure, reproducible research, Linux or HPC environments, and software or platform development.
• We are looking for clear communication skills with scientific, technical, medical, and business partners, and comfort working in a collaborative, multidisciplinary team.

Responsibilities:

• We lead AI and machine learning projects that address clinical development, biomarker, operational, and decision-support needs.
• We design, build, test, and refine modern deep learning models for text, graphs, biological sequences, and clinical data.
• We develop generative AI applications using foundation models, pre-trained models, and large language models.
• We run rigorous, reproducible AI experiments on internal and public datasets to generate publishable scientific results.
• We partner with engineering teams to package methods into applications, platforms, and scalable validated solutions.
• We mentor colleagues, share knowledge, and represent the team through publications, presentations, and external collaborations.

Technologies:

• AI
• Support
• Linux
• Machine Learning
• Python

More:

We are UCB, a global biopharmaceutical company focused on neurology and immunology, with more than 9,000 people worldwide inspired by patients and driven by science. We are hiring a Principal Computational Methodologist to join our Advanced Methods and Data Science team within Biometrics and Data Science, based in Brussels, Slough, or Raleigh. This is a permanent hybrid-first role, with 40% of time spent in the office unless otherwise stated. We offer a caring, supportive culture where everyone feels included, respected, and able to do their best work, and we provide opportunities to grow and shape your own career path. Our teams collaborate across clinical, statistical, molecular, operational, engineering, IT, governance, and compliance functions, and we also connect with academic, technology, and industry partners.

last updated 36 week of 2026